As more and more research is done on white matter morphology, the obvious question to ask is whether differences can be found between individuals or between groups, ie patients vs controls. Before we begin, I’d like to summarize some important acquisition issues.

Data Acquisition

About native and Talairach space

We recommend computing the tensor and derived measures in native space (that is the space as the data was scanned in), and to do the group analysis in common space by converting the scalar FA/ADC maps to TAL space. This prevents introducing artefacts in the tensor data by interpolation. Interpolation of a tensor is not trivial and may introduce tensor deformation in the processing. For more information, see reference [?].